翻訳と辞書 Words near each other ・ 7,14-Dibenzpyrenequinone ・ 7,62 ITKK 31 VKT ・ 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase ・ 7,8-Dihydroneopterin triphosphate ・ 7,8-Dihydroxyflavone ・ 7,8-dihydroxykynurenate 8,8a-dioxygenase ・ 7,N,N-TMT ・ 7-0-5 ・ 7-1-1 ・ 7-30 Waters ・ 7-ACA ・ 7-Aminoactinomycin D ・ 7-Bone Roast ・ 7-carboxy-7-deazaguanine synthase ・ 7-Chloro-L-tryptophan oxidase ・ 7-Chlorokynurenic acid ・ 7-cube ・ 7-cubic honeycomb ・ 7-cyano-7-deazaguanine synthase ・ 7-day SEC yield ・ 7-Dehydrocholesterol ・ 7-Dehydrocholesterol reductase ・ 7-Dehydrodesmosterol ・ 7-Dehydrositosterol ・ 7-demicube ・ 7-demicubic honeycomb ・ 7-Deoxyloganetic acid ・ 7-Deoxyloganic acid ・ 7-deoxyloganin 7-hydroxylase ・ 7-Dimethylallyltryptophan synthase Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク 7-Chlorokynurenic acid ： ウィキペディア英語版 7-Chlorokynurenic acid 7-Chlorokynurenic acid (7-CKA) is a drug that acts as a potent and selective noncompetitive antagonist of the glycine site of the NMDA receptor. It produces ketamine-like rapid antidepressant effects in animal models of depression. However, 7-CKA is unable to cross the blood-brain-barrier, and for this reason, is unsuitable for clinical use. As a result, a centrally-penetrant prodrug of 7-CKA, 4-chlorokynurenine (AV-101), has been developed for use in humans, and is being studied in clinical trials as a potential treatment for major depressive disorder.〔 In addition to antagonizing the NMDA receptor, 7-CKA also acts as a potent inhibitor of the reuptake of glutamate into synaptic vesicles (or as a vesicular glutamate reuptake inhibitor), an action that it mediates via competitive blockade of vesicular glutamate transporters (Ki = 0.59 mM). ==See also== * 5,7-Dichlorokynurenic acid * Evans blue * Kynurenic acid * Xanthurenic acid 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「7-Chlorokynurenic acid」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.